Nagesh B Pai

Neurobiology of Addiction

Nagesh B Pai – Professor and Academic Leader of Psychiatry

He is currently Foundation Professor of Psychiatry at the Graduate Medicine, Faculty of Science, Health & Medicine, and University of Wollongong, Australia. He Chairs the Clinical Phase of MD Program and has chaired NSW Specialist International Medical Graduates in Psychiatry upskilling project and is the Facilitator of Australian Clinical Practice skills course of The Royal Australian and New Zealand College of Psychiatrists. He was the Medical Director of Illawarra Health Medical Research Institute. Mental Health Research stream (2009-2012) and has been a supervisor for Higher degree Research programs. He has completed basic Psychiatry Training at NIMHANS, Bangalore He has also obtained CCST (UK) in General Adult Psychiatry

He underwent Post graduate training in Health Service Research and Development and Medical Education and has been a Fellow of a number of Psychiatric Organisations as well as Medical administration, Hospital management and Medical education. He has been accepted as an International Distinguished Fellow of the American Psychiatric Association, member of American Society of clinical Psychopharmacology and Fellow of the College of International Neuropsychopharmacology.

Dr. Nagesh Pai will be the convenor for the symposium “Brain in addiction –Bench to Bedside”.

Abstract of his talk:

Neurobiology of Addiction

Addiction is a chronic, relapsing disorder characterized by craving, compulsive drug use, and loss of control over limiting drug intake. Understanding of biological basis of addiction, has advanced significantly over the last 3 decades in part due to major progress in genetics and neuroscience research and to the development of new technologies. This presentation will update the neurobiological processes through which biological and socio-cultural factors contribute to resilience against or vulnerability for drug use and addiction .We will also review the recent understanding of  the aberrant, impulsive, and compulsive behaviours that are characteristic of addiction in addition to findings on the desensitization of reward circuits, which dampens the ability to feel pleasure and the motivation to pursue everyday activities; the increasing strength of conditioned responses and stress reactivity, which results in increased cravings for alcohol and other drugs and negative emotions when these cravings are not sated; and the weakening of the brain regions involved in executive functions such as decision making, inhibitory control, and self-regulation that leads to repeated relapse. These advances in our understanding of brain development and of the role of genes and environment on brain structure and function have built a foundation on which to develop more effective tools to prevent and treat substance use disorder.

My Sessions

Neurobiology of Addiction